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When I started my clinical training in hematology around 1970, the outcome of patients with acute myeloid (or myelogenous) leukemia (AML) was invariably poor. The diagnosis was based solely on morphology. As a result, it was not always possible to distinguish AML from acute lymphoblastic leukemia with confidence. Only a few textbooks about leukemias had been published, and one devoted to AML, if available, would have been a thin pamphlet. In my own library, I have a book on adult leukemias from the Cancer Treatment and Research series published by Kluwer (now Springer) in 1982. In those days, combination chemotherapy
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