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Correspondence
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Volume 357:2306-2307 November 29, 2007 Number 22
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Progesterone and Preterm Birth

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 by Rouse, D. J.
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 by Fonseca, E. B.
-PubMed Citation
To the Editor: The reports by Fonseca et al. and Rouse et al. (Aug. 2 issue)1,2 raise important issues regarding the efficacy and safety of progestins for the prevention of preterm birth. An essential difference between the two study designs is that the study by Fonseca et al. evaluated progesterone administration for a defined pathologic condition, premature cervical shortening, and the the study by Rouse et al. assessed treatment for a risk factor, twin pregnancy.

Rouse et al. observed an increase in deliveries that occurred before 28 weeks of gestation and a nonsignificant increase in newborns with birth weights below . . . [Full Text of this Article]


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