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A 39-year-old woman with β-thalassemia major had required a transfusion of approximately 1 unit of red blood cells per month since she was 1 year old. Because of iron overload, chelation therapy was started when she was 6 years old. She presented with pain, swelling, and decreased joint mobility in both ankles. Laboratory evaluation was notable for a hemoglobin level of 8.3 g per deciliter, a mean corpuscular volume of 81.3 µm3, and a red-cell distribution width of 26.7%. Her older brother had also had β-thalassemia major and died of heart failure at 31 years of age. Anteroposterior (Panel . . . [Full Text of this Article] |
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