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Editorial
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Volume 357:2397-2399 December 6, 2007 Number 23
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Manipulation of the Growth Hormone Axis in Patients with HIV Infection
Marc R. Blackman, M.D.

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 by Falutz, J.
-PubMed Citation
Patients with human immunodeficiency virus (HIV) infection often have a reduced mass of skeletal muscle and bone and a maldistribution of body fat. Loss of muscle mass, strength, and function are integral to the AIDS wasting syndrome and are associated with resistance to the anabolic effects of growth hormone. Administration of growth hormone in relatively high daily doses for 12 weeks improves muscle mass, strength, and function but leads to excess salt and water retention, the carpal tunnel syndrome, glucose intolerance, and insulin resistance, whereas the use of somewhat lower doses or an alternate-day regimen elicits similar beneficial effects with . . . [Full Text of this Article]


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From the Research Service, Veterans Affairs Medical Center, Washington, DC.


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