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Volume 357:2408-2410 December 6, 2007 Number 23
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Myocardial Reperfusion Injury

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by Yellon, D. M.
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To the Editor: In the article by Yellon and Hausenloy (Sept. 13 issue)1 on myocardial perfusion injury, I would like to challenge the statement about therapeutic hypothermia, since this method is emerging as a novel way to reduce final myocardial infarct size. Therapeutic cooling showed a significant ST-segment resolution in the group with anterior myocardial infarction in the Cooling as an Adjunctive Therapy to Percutaneous Intervention in Patients with Acute Myocardial Infarction (COOL-MI) trial.2 Patients with anterior-wall infarction and a core body temperature of 35°C or less before angioplasty had a reduction in the final infarct size, as compared with . . . [Full Text of this Article]



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