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Volume 357:2410-2411 December 6, 2007 Number 23
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Anabolic Therapies for Osteoporosis

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To the Editor: In their review of anabolic therapies for osteoporosis, Canalis et al. (Aug. 30 issue)1 mention contraindications to teriparatide use, including skeletal malignant conditions. We wish to add an additional caution concerning the use of this drug in patients with a history of cancer. Patients with non–small-cell lung cancer, breast cancer, and other cancers have been shown to have micrometastatic tumor cells in the bone marrow that are associated with poor outcomes.2,3 It is not known whether patients without evidence of disease for many years have "micrometastases" in the bone marrow as well. The high-bone-turnover state (sequential osteoblastic . . . [Full Text of this Article]


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