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Correspondence
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Volume 357:2411-2412 December 6, 2007 Number 23
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Growth of a Meningioma in a Transsexual Patient after Estrogen–Progestin Therapy

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To the Editor: A 28-year-old male-to-female transsexual patient presented with severe headache and visual disturbances; clinical examination showed visual impairment, with bitemporal inferior visual-field defects, papilledema of the left eye, and optic atrophy of the right eye. The patient was euphoric and confused. Personality changes noted during the previous 4 months had been attributed by family members to the new gender identity of the patient. The patient had been taking a feminizing endocrine regimen of ethinyl estradiol (100 µg per day orally) and cyproterone acetate (100 mg per day orally) for the previous 5 years. After 2 years of hormone . . . [Full Text of this Article]


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