FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 357:2482-2494 December 13, 2007 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text PowerPoint Slide Set CME Exam Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

Platelets are essential for primary hemostasis and repair of the endothelium, but they also play a key role in the development of acute coronary syndromes and contribute to cerebrovascular events. In addition, they participate in the process of forming and extending atherosclerotic plaques. Atherosclerosis is a chronic inflammatory process,¹ and inflammation is an important component of acute coronary syndromes.² The relation between chronic and acute vascular inflammation is unclear, but platelets are a source of inflammatory mediators,³ and the activation of platelets by inflammatory triggers may be a critical component of atherothrombosis.⁴ This review article describes the role of platelets . . . [Full Text of this Article]

Platelets in Primary Hemostasis

Platelet Activation

Clinical Implications

Platelets and Development of Atherosclerotic Lesions

Platelet-Derived Mediators of Inflammation

Reactive Oxygen Species and Platelet Activation

Platelets in Atherogenesis in Humans

Platelets and Arterial Thrombosis

Platelet Activation in Acute Coronary Syndromes

Platelet Activation in Acute Ischemic Stroke

Thromboxane A₂ and Prostacyclin

ADP

Thrombin

Future Directions

Source Information

From the Center of Excellence on Aging, G. d'Annunzio University Foundation, Chieti (G.D.), and the Department of Pharmacology, Catholic University School of Medicine, Rome (C.P.) — both in Italy.

Address reprint requests to Dr. Patrono at Università Cattolica del S. Cuore, Largo F. Vito 1, 00168 Rome, Italy, or at carlo.patrono@rm.unicatt.it.

Related Letters:

Platelet Activation and Atherothrombosis
Kapoor J. R., Patrono C., Davì G.
Extract | Full Text | PDF  
N Engl J Med 2008; 358:1638-1639, Apr 10, 2008. Correspondence

This article has been cited by other articles:

• Berger, J. S., Bhatt, D. L., Cannon, C. P., Chen, Z., Jiang, L., Jones, J. B., Mehta, S. R., Sabatine, M. S., Steinhubl, S. R., Topol, E. J., Berger, P. B. (2009). The Relative Efficacy and Safety of Clopidogrel in Women and Men: A Sex-Specific Collaborative Meta-Analysis. J Am Coll Cardiol 54: 1935-1945 [Abstract] [Full Text]  
• Licht, C., Pluthero, F. G., Li, L., Christensen, H., Habbig, S., Hoppe, B., Geary, D. F., Zipfel, P. F., Kahr, W. H. A. (2009). Platelet-associated complement factor H in healthy persons and patients with atypical HUS. Blood 114: 4538-4545 [Abstract] [Full Text]  
• Gritters-van den Oever, M., Grooteman, M. P. C., Bartels, P. C. M., Blankestijn, P. J., Bots, M. L., van den Dorpel, M. A., Schoorl, M., Schoorl, M., ter Wee, P. M., Nube, M. J. (2009). Post-dilution haemodiafiltration and low-flux haemodialysis have dissimilar effects on platelets: a side study of CONTRAST. Nephrol Dial Transplant 24: 3461-3468 [Abstract] [Full Text]  
• Momi, S., Falcinelli, E., Giannini, S., Ruggeri, L., Cecchetti, L., Corazzi, T., Libert, C., Gresele, P. (2009). Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivo. JEM 206: 2365-2379 [Abstract] [Full Text]  
• Dangas, G., Mehran, R., Guagliumi, G., Caixeta, A., Witzenbichler, B., Aoki, J., Peruga, J. Z., Brodie, B. R., Dudek, D., Kornowski, R., Rabbani, L. E., Parise, H., Stone, G. W., for the HORIZONS-AMI Trial Investigators, (2009). Role of Clopidogrel Loading Dose in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Angioplasty: Results From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial. J Am Coll Cardiol 54: 1438-1446 [Abstract] [Full Text]  
• Collet, J.-P., Montalescot, G. (2009). Review: Platelet Function Testing and Implications for Clinical Practice. J CARDIOVASC PHARMACOL THER 14: 157-169 [Abstract]  
• Neumuller, O., Hoffmeister, M., Babica, J., Prelle, C., Gegenbauer, K., Smolenski, A. P. (2009). Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. Blood 114: 1396-1404 [Abstract] [Full Text]  
• Wallentin, L. (2009). P2Y12 inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use. Eur Heart J 30: 1964-1977 [Abstract] [Full Text]  
• Verstuyft, C., Simon, T., Kim, R. B. (2009). Personalized medicine and antiplatelet therapy: ready for prime time?. Eur Heart J 30: 1943-1963 [Full Text]  
• Van de Werf, F. (2009). New antithrombotic agents: are they needed and what can they offer to patients with a non-ST-elevation acute coronary syndrome?. Eur Heart J 30: 1695-1702 [Abstract] [Full Text]  
• Rivera, J., Lozano, M. L., Navarro-Nunez, L., Vicente, V. (2009). Platelet receptors and signaling in the dynamics of thrombus formation. haematol 94: 700-711 [Abstract] [Full Text]  
• KOTTKE-MARCHANT, K. (2009). Importance of platelets and platelet response in acute coronary syndromes. Cleveland Clinic Journal of Medicine 76: S2-S7 [Abstract] [Full Text]  
• Smyth, S. S., Woulfe, D. S., Weitz, J. I., Gachet, C., Conley, P. B., Goodman, S. G., Roe, M. T., Kuliopulos, A., Moliterno, D. J., French, P. A., Steinhubl, S. R., Becker, R. C., for the 2008 Platelet Colloquium Participants, (2009). G-Protein-Coupled Receptors as Signaling Targets for Antiplatelet Therapy. Arterioscler. Thromb. Vasc. Bio. 29: 449-457 [Abstract] [Full Text]  
• Kim, M.-H., Curry, F.-R. E., Simon, S. I. (2009). Dynamics of neutrophil extravasation and vascular permeability are uncoupled during aseptic cutaneous wounding. Am. J. Physiol. Cell Physiol. 296: C848-C856 [Abstract] [Full Text]  
• Santilli, F., Rocca, B., De Cristofaro, R., Lattanzio, S., Pietrangelo, L., Habib, A., Pettinella, C., Recchiuti, A., Ferrante, E., Ciabattoni, G., Davi, G., Patrono, C. (2009). Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays implications for aspirin "resistance".. J Am Coll Cardiol 53: 667-677 [Abstract] [Full Text]  
• Patrono, C., Baigent, C. (2009). Low-Dose Aspirin, Coxibs, and other NSAIDS: A Clinical Mosaic Emerges. Mol. Interv. 9: 31-39 [Abstract] [Full Text]  
• Bozza, F. A., Shah, A. M., Weyrich, A. S., Zimmerman, G. A. (2009). Amicus or Adversary: Platelets in Lung Biology, Acute Injury, and Inflammation. Am. J. Respir. Cell Mol. Bio. 40: 123-134 [Abstract] [Full Text]  
• Pastor-Perez, F. J., Marin, F., Manzano-Fernandez, S., Lip, G. Y.H. (2008). Is thrombogenesis related to residual platelet function in ischaemic heart disease?. Eur Heart J 29: 3065-3065 [Full Text]  
• Zimarino, M., De Caterina, R. (2008). Long-term treatment strategies for atherothrombotic disease: do platelets define the course?. Eur Heart J Suppl 10: I8-I13 [Abstract] [Full Text]  
• Nachman, R. L., Rafii, S. (2008). Platelets, Petechiae, and Preservation of the Vascular Wall. NEJM 359: 1261-1270 [Full Text]  
• Gritters, M., Borgdorff, P., Grooteman, M. P. C., Schoorl, M., Schoorl, M., Bartels, P. C. M., Tangelder, G.-J., Nube, M. J. (2008). Platelet activation in clinical haemodialysis: LMWH as a major contributor to bio-incompatibility?. Nephrol Dial Transplant 23: 2911-2917 [Abstract] [Full Text]  
• Furie, B., Furie, B. C. (2008). Mechanisms of Thrombus Formation. NEJM 359: 938-949 [Full Text]  
• Santilli, F., Romano, M., Recchiuti, A., Dragani, A., Falco, A., Lessiani, G., Fioritoni, F., Lattanzio, S., Mattoscio, D., De Cristofaro, R., Rocca, B., Davi, G. (2008). Circulating endothelial progenitor cells and residual in vivo thromboxane biosynthesis in low-dose aspirin-treated polycythemia vera patients. Blood 112: 1085-1090 [Abstract] [Full Text]  
• Herget-Rosenthal, S. (2008). Reply. Nephrol Dial Transplant 23: 2702-2703 [Full Text]  
• deGoma, E. M., deGoma, R. L., Rader, D. J. (2008). Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches.. J Am Coll Cardiol 51: 2199-2211 [Abstract] [Full Text]  
• Patrono, C., Baigent, C., Hirsh, J., Roth, G. (2008). Antiplatelet Drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133: 199S-233S [Abstract] [Full Text]  
• Kapoor, J. R., Patrono, C., Davi, G. (2008). Platelet Activation and Atherothrombosis. NEJM 358: 1638-1639 [Full Text]