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Previous Volume 357:2496-2505 December 13, 2007 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Presentation of Case

Dr. Michael Sherling (Dermatology): A 44-year-old woman was admitted to this hospital because of generalized, painful, ulcerated cutaneous lesions.

The patient had been well, except for eczema, until 4 years before admission, when erosions on the scalp developed, followed by a generalized papular skin eruption. Betamethasone dipropionate and cephalexin were prescribed, without improvement. Examination by a dermatologist 2.3 years before admission revealed scarring alopecia and multiple hyperkeratotic erythematous plaques on the trunk and arms. Pathological examination of biopsy specimens of two lesions on the left arm were reported to show hypertrophic lichenoid dermatitis with eosinophilia. The results of laboratory tests . . . [Full Text of this Article]

Differential Diagnosis

Generalized Hyperkeratotic Papulonodules

            Disseminated Squamous-Cell Carcinomas

            Multiple Keratoacanthomas

            Verrucous Carcinomas

            Lupus Erythematosus

            Infections

            Halogenoderma

Erythematous Nodules and Plaques with Ulceration

            Mycosis Fungoides

            CD30+ Cutaneous Lymphoproliferative Disorders

            Pagetoid Reticulosis

            Aggressive Epidermotropic CD8+ Cytotoxic T-Cell Lymphoma

Interpretation of This Case

Clinical Diagnosis

Dr. Vincent Liu's Diagnosis

Pathological Discussion

Discussion of Management

Anatomical Diagnosis

Source Information

From the Departments of Dermatology and Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City (V.L.); and the Division of Medical Oncology, Dana–Farber Cancer Institute (C.S.C.); the Department of Pathology, Massachusetts General Hospital (A.Z.Y.); and the Departments of Medicine (C.S.C.) and Pathology (A.Z.Y.), Harvard Medical School.

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