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Correspondence
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Volume 357:2517-2518 December 13, 2007 Number 24
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Rheumatoid Arthritis, Systemic Lupus Erythematosus, and STAT4

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by Remmers, E. F.
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To the Editor: Remmers and colleagues (Sept. 6 issue)1 show that a variant allele of STAT4 confers an increased risk of both rheumatoid arthritis and systemic lupus erythematosus and thus suggest a shared pathway for these diseases. If two diseases share a common pathogenic pathway, the expected prevalence of their concurrence should exceed the chance probability of having both diseases. The clinical coexistence of rheumatoid arthritis and systemic lupus erythematosus is rare.2,3,4,5 In the largest reported cohort of patients with this condition, the observed prevalence of concurrent rheumatoid arthritis and systemic lupus erythematosus was 0.09% among patients with inflammatory arthritis . . . [Full Text of this Article]



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