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Correspondence
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Volume 357:2522-2524 December 13, 2007 Number 24
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APOE Kyoto Mutation in European Americans with Lipoprotein Glomerulopathy

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To the Editor: Lipoprotein glomerulopathy is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, and distinctive lipoprotein thrombi in glomerular capillaries.1 It mainly affects people of Japanese and Chinese origin; in these populations, it is associated with novel mutations in APOE, the gene that encodes apolipoprotein E.2 To date, only two cases of lipoprotein glomerulopathy have been documented in whites (both of whom were European), but genotyping was not performed in these patients.

We have identified the disease in two unrelated American men of European ancestry who presented with edema and proteinuria in the nephrotic range. The results . . . [Full Text of this Article]



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