The gene known variously as p53, TP53, and Trp53 is currentlyfeatured in nearly 45,000 published articles listed in PubMed— a remarkable number suggesting that the protein productof this gene, p53, is one of the most important molecules inbiology. When it was discovered in 1979, the p53 phosphoprotein(molecular mass, 53 kD) was postulated to have "a crucial rolein the modulation of the transformed state."1 This idea hasfound support in innumerable studies, including the one reportedon by Poeta et al. in this issue of the Journal (pages 2552–2561),in which somatic mutations in TP53. . . [Full Text of this Article]
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Dr. Foulkes is the director of the Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montreal.
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