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Previous Volume 357:2601-2614 December 20, 2007 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Increasingly potent immunosuppressive agents have dramatically reduced the incidence of rejection of transplanted organs while increasing patients' susceptibility to opportunistic infections and cancer.^1,2 At the same time, patterns of opportunistic infections after transplantation have been altered by routine antimicrobial prophylaxis for Pneumocystis carinii (also called P. jirovecii) and cytomegalovirus. These patterns have also been altered by the emergence of new clinical syndromes (e.g., polyomavirus type BK nephropathy) and by infections due to organisms with antimicrobial resistance. New quantitative molecular and antigen-based microbiologic assays detect previously unrecognized transplantation-associated pathogens such as lymphocytic choriomeningitis virus. These assays are used in the . . . [Full Text of this Article]

General Concepts

Risk of Infection

Epidemiologic Exposures

            Donor-Derived Infections and Screening

            Recipient-Derived Infections and Detection

            Nosocomial Infections and Antimicrobial Resistance

            Community Infections

Net State of Immunosuppression and Monitoring of Immune Function

Prevention of Infection

Changing the Pattern of Infection

Early Post-Transplantation Period

Intermediate Post-Transplantation Period

Late Post-Transplantation Period

Common Infections in Transplantation

Cytomegalovirus Infection

            Epidemiology

            Prevention

            Diagnosis and Therapy

Epstein–Barr Virus and Post-Transplantation Lymphoproliferative Disorder

Polyomaviruses BK and JC

Central Nervous System Infection

Pneumonitis and Pneumocystis Infection

Conclusions

Source Information

From the Transplant Infectious Disease and Compromised Host Program, Massachusetts General Hospital, and Harvard Medical School, Boston.

Address reprint requests to Dr. Fishman at the Transplant Infectious Disease and Compromised Host Program, Massachusetts General Hospital, 55 Fruit St., GRJ 504, Boston, MA 02114, or at jfishman@partners.org.

Related Letters:

Infection in Solid-Organ Transplant Recipients
Cross T. J.S., Berry P. A., Burroughs A. K.
Extract | Full Text | PDF  
N Engl J Med 2008; 358:1302, Mar 20, 2008. Correspondence

This article has been cited by other articles:

• Fishman, J. A., Gonzalez, R. G., Branda, J. A. (2008). Case 11-2008 -- A 45-Year-Old Man with Changes in Mental Status after Liver Transplantation. NEJM 358: 1604-1613 [Full Text]  
• Cross, T. J.S., Berry, P. A., Burroughs, A. K. (2008). Infection in Solid-Organ Transplant Recipients. NEJM 358: 1302-1302 [Full Text]