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Previous Volume 357:2616-2623 December 20, 2007 Number 25 Next

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Presentation of Case

Dr. Ruth Ann Vleugels (Dermatology): A 5-month-old girl was seen in the pediatric dermatology clinic because of a rash. She had been well until 3 months of age, when her parents noticed a red, slightly raised lesion on her left cheek, 2 mm in diameter, which did not seem to cause discomfort. It grew slowly over the next several weeks, with swelling at times but no frank blistering. Approximately 1 week before the current evaluation, additional reddish-brown papules, 2 to 5 mm in diameter, appeared, first on the forehead and then on the chest, abdomen, back, arms, and legs. The . . . [Full Text of this Article]

Differential Diagnosis

Urticaria Pigmentosa

Disseminated Juvenile Xanthogranuloma

Generalized Eruptive Histiocytosis

Leukemia Cutis

Dr. Melissa M. Burnett's Diagnosis

Pathological Discussion

Discussion of Management

Acute Leukemia in Infancy

Treatment of Pediatric AML

Risk Stratification

            Age Less Than 1 Year

            Leukemia Cutis

            Abnormalities of Chromosome 11q23 at the MLL Locus

Anatomical Diagnosis

Source Information

From the Departments of Pediatric Dermatology (M.M.B.), Pediatric Hematology–Oncology (M.S.H.), and Pathology (R.M.S.), Massachusetts General Hospital, Boston; the Department of Pediatric Dermatology, Cambridge Hospital (Cambridge Health Alliance), Cambridge, MA (M.M.B.); and the Departments of Dermatology (M.M.B.), Pediatrics (M.S.H.), and Pathology (R.M.S.), Harvard Medical School, Boston.

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