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Editorial
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Volume 357:2625-2627 December 20, 2007 Number 25
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Balancing Efficacy and Toxicity in Kidney-Transplant Immunosuppression
Alan B. Leichtman, M.D.

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-Related Article
 by Ekberg, H.
-PubMed Citation
Although protocols differ among transplantation centers, most immunosuppressive strategies for kidney-transplant recipients are built on two core practices: delivery of immunosuppression in two phases, usually termed induction and maintenance, and the concurrent use of several immunosuppressive medications that work at various sites in the cell cycle and have nonoverlapping toxic effects. In general, the induction phase involves the initial use of the same oral immunosuppressive medications that are prescribed at lower doses during long-term maintenance. Induction doses are reduced during the first 2 to 4 months after transplantation until maintenance levels are achieved. Induction may also include the administration of . . . [Full Text of this Article]


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From the Department of Medicine, Division of Nephrology, University of Michigan Medical School, Ann Arbor.




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