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Correspondence
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Volume 357:2634-2636 December 20, 2007 Number 25
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Saline or Albumin for Fluid Resuscitation in Traumatic Brain Injury

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by The SAFE Study Investigators
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To the Editor: The Saline versus Albumin Fluid Evaluation (SAFE) study investigators (Aug. 30 issue)1 report that in their post hoc follow-up study of patients from the SAFE study who had traumatic brain injury (the SAFE–TBI study), resuscitation with 4% albumin resulted in higher mortality at 2 years than resuscitation with saline. This requires careful consideration to avoid overinterpretation. The main SAFE study investigated two types of resuscitation fluids during the first 28 days of intensive care in a large and heterogeneous collective, with patients who had traumatic brain injury representing only a small subgroup.2 Therefore, several shortcomings limit a . . . [Full Text of this Article]



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