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Correspondence
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Volume 357:2637-2638 December 20, 2007 Number 25
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Reversal of Pacing-Induced Heart Failure by Left Ventricular Apical Pacing

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To the Editor: Children with congenital complete atrioventricular block often require lifelong pacemaker therapy. Although such therapy restores a normal heart rate, it also results in dyssynchronous left ventricular activation and contraction and compromises left ventricular function.1,2,3 These effects are most pronounced during right ventricular pacing, the predominant pacing site in children and adults. Eventually, heart failure develops in 6 to 7% of children who undergo long-term right ventricular pacing.2

The harmful effects of right ventricular pacing initiated the search for pacing modes that would maintain or restore synchronous activation — in other words, biventricular pacing and alternative single-site ventricular . . . [Full Text of this Article]


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