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Previous Volume 357:266-281 July 19, 2007 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Once foods were fortified with vitamin D and rickets appeared to have been conquered, many health care professionals thought the major health problems resulting from vitamin D deficiency had been resolved. However, rickets can be considered the tip of the vitamin D–deficiency iceberg. In fact, vitamin D deficiency remains common in children and adults. In utero and during childhood, vitamin D deficiency can cause growth retardation and skeletal deformities and may increase the risk of hip fracture later in life. Vitamin D deficiency in adults can precipitate or exacerbate osteopenia and osteoporosis, cause osteomalacia and muscle weakness, and increase the . . . [Full Text of this Article]

Sources and Metabolism of Vitamin D

Definition and Prevalence of Vitamin D Deficiency

Calcium, Phosphorus, and Bone Metabolism

Osteoporosis and Fracture

Muscle Strength and Falls

Nonskeletal Actions of Vitamin D

Latitude, Vitamin D Deficiency, and Chronic Diseases

Cancer

Autoimmune Diseases, Osteoarthritis, and Diabetes

Cardiovascular Disease

Vitamin D Deficiency and Other Disorders

Schizophrenia and Depression

Lung Function and Wheezing Illnesses

Causes of Vitamin D Deficiency

Vitamin D Requirements and Treatment Strategies

Children and Adults

Breast-Fed Infants and Children

Patients with Chronic Kidney Disease

Malabsorption and Medication

Sunlight and Artificial Ultraviolet B Radiation

Vitamin D Intoxication

Conclusions

Source Information

From the Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston.

Address reprint requests to Dr. Holick at Boston University School of Medicine, 715 Albany St., M-1013, Boston, MA 02118, or at mfholick@bu.edu.

Related Letters:

Vitamin D Deficiency
Bouillon R., Norman A. W., Lips P., Cava R. C., Javier A. N. D., Howe W. R., Dellavalle R., Baroncelli G. I., Holick M. F.
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N Engl J Med 2007; 357:1980-1982, Nov 8, 2007. Correspondence

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