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Previous Volume 357:283-291 July 19, 2007 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Presentation of Case

A 38-year-old woman was seen in the Gastrointestinal Cancer Genetics Clinic of this hospital because of a family history of breast and gastric cancer.

Approximately 15 months earlier, mild chronic gastrointestinal symptoms, including dyspepsia, heartburn, and midabdominal discomfort, increased in severity and began to occur daily. The symptoms did not resolve with antacid therapy. She had lost approximately 2.3 kg (5 lb) during this time, which she attributed to the stress of caring for her maternal aunt, who was dying of gastric cancer. Seven months before admission, an endoscopic examination of the upper gastrointestinal tract, performed at another hospital, was . . . [Full Text of this Article]

Differential Diagnosis

Hereditary Breast Cancer Syndromes

Hereditary Gastric Cancer Syndromes

            Colorectal Cancer Syndromes

            Hereditary Diffuse Gastric Cancer Syndrome

Genetic Testing

Discussion of Management

Management of the Risk of Gastric Cancer

Prophylactic Gastrectomy

            Technical Considerations

            Morbidity and Mortality

Pathological Discussion

Anatomical Diagnosis

Source Information

From the Gastroenterology Unit (D.C.C.), the Division of Surgical Oncology and Department of Surgery (S.S.Y.), the Department of Pathology (G.Y.L.), and the Center for Cancer Risk Analysis (D.C.C., D.P.), Massachusetts General Hospital; and the Departments of Medicine (D.C.C.), Surgery (S.S.Y.), and Pathology (G.Y.L.), Harvard Medical School.

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