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Volume 357:303-304 July 19, 2007 Number 3
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Omeprazole before Endoscopy in Patients with Gastrointestinal Bleeding

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by Lau, J. Y.
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To the Editor: Lau et al. (April 19 issue)1 suggest the infusion of high-dose omeprazole before endoscopy to reduce the need for endoscopic therapy in patients with non–aspirin-related bleeding peptic ulcers. We find it difficult to support this proposal, since this treatment was not associated with more favorable outcomes. Despite fewer endoscopic signs of bleeding, patients given omeprazole fared no better than those given placebo with respect to mortality, transfusion requirements, and the need for surgery.

The role of early use of a proton-pump inhibitor in unselected patients with upper gastrointestinal bleeding is an important clinical issue that should be . . . [Full Text of this Article]



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