FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 357:304-306 July 19, 2007 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Francis, C. W. PubMed Citation

To the Editor: Francis (April 5 issue)¹ states that an 8-hour dosing schedule of unfractionated heparin may be preferable to a 12-hour dosing schedule. However, a recent meta-analysis that included 12 studies and 7978 patients has shown that a regimen of 5000 U of unfractionated heparin every 8 hours is associated with a significant risk of major bleeding, as compared with a regimen of unfractionated heparin given every 12 hours (96% vs. 35%, P<0.001).² Furthermore, 8-hour doses of unfractionated heparin are associated with an increased risk of heparin-induced thrombocytopenia.^3,4 It is also important to consider that, according to another meta-analysis,⁵ . . . [Full Text of this Article]

HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  TERMS OF USE  |  HELP  |  beta.nejm.org Comments and questions? Please contact us. The New England Journal of Medicine is owned, published, and copyrighted © 2009 Massachusetts Medical Society. All rights reserved.