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Correspondence
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Volume 357:422-424 July 26, 2007 Number 4
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Radiofrequency Ablation of a Tumor Causing Oncogenic Osteomalacia

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To the Editor: Oncogenic osteomalacia is a rare syndrome that is usually driven by small, mesenchymal tumors that express phosphatonins, proteins that decrease the abundance of sodium–phosphate cotransporters in the proximal renal tubule. This decrease causes renal phosphate wasting and leads to the clinical features of oncogenic osteomalacia, which include hyperphosphaturia, hypophosphatemia, reduced or abnormal serum 1,25-dihydroxyvitamin D levels, and osteomalacia.1,2

The standard treatment of oncogenic osteomalacia is surgical excision of the mesenchymal tumor, which rapidly and permanently abrogates all symptoms. However, tumor removal can be complicated, because the lesion is usually small and difficult to distinguish from the surrounding . . . [Full Text of this Article]



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