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At the dawn of the era of personalized medicine, we are poised to understand how patterns of genes and proteins can influence the risk that a disease will develop in an asymptomatic person. We will determine the risk by calculating risk scores and categorizing patients on the basis of those scores. The idea of quantifying risk by means of numeric formulas and then labeling asymptomatic persons as diseased is controversial, but it is not a new concept. In Prescribing by Numbers, Greene reviews the history of the treatment of hypertension, diabetes, and hypercholesterolemia and addresses the idea of treating asymptomatic
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