FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 357:580-587 August 9, 2007 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text PowerPoint Slide Set Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

Drug-induced thrombocytopenia can be caused by dozens, perhaps hundreds, of medications. Because thrombocytopenia can have many other causes, the diagnosis of drug-induced thrombocytopenia can easily be overlooked. On occasion, outpatients with drug-induced thrombocytopenia are treated for autoimmune thrombocytopenia and can have two or three recurrences before the drug causing the disorder is identified.¹ In acutely ill, hospitalized patients, drug-induced thrombocytopenia can be overlooked because thrombocytopenia is attributed to sepsis, the effect of coronary-artery bypass surgery, or some other underlying condition. Although drug-induced thrombocytopenia is uncommon, it can have devastating, even fatal consequences that can usually be prevented simply by discontinuing . . . [Full Text of this Article]

Presentation

Incidence

Causative Agents

Pathogenesis

Thrombocytopenia Induced by Quinine and Other Drugs

Thrombocytopenia Induced by Platelet Inhibitors

Thrombocytopenia Induced by Abciximab

Thrombocytopenia Due to Drug-Induced Autoantibodies

Diagnosis

Treatment and Prognosis

Source Information

From the Department of Medicine, Medical College of Wisconsin (R.H.A.), and the Blood Research Institute, BloodCenter of Wisconsin (R.H.A., D.W.B.) — both in Milwaukee.

Address reprint requests to Dr. Aster at the Blood Research Institute, BloodCenter of Wisconsin, 8727 Watertown Plank Rd., Milwaukee, WI 53226-3548, or at richard.aster@bcw.edu.

Related Letters:

Drug-Induced Immune Thrombocytopenia
Naina H. V.K., Harris S., Matzdorff A. C., Cathomas R., Goldhirsch A., von Moos R., Aster R. H., Bougie D. W.
Extract | Full Text | PDF  
N Engl J Med 2007; 357:1869-1871, Nov 1, 2007. Correspondence

This article has been cited by other articles:

• Cathomas, R., von Moos, R. (2009). Severe drug-induced thrombocytopenia after treatment with trastuzumab but not with lapatinib. Ann Oncol 20: 1606-1607 [Full Text]  
• Greinacher, A., Kohlmann, T., Strobel, U., Sheppard, J.-A. I., Warkentin, T. E. (2009). The temporal profile of the anti-PF4/heparin immune response. Blood 113: 4970-4976 [Abstract] [Full Text]  
• Andersohn, F., Konzen, C., Bronder, E., Klimpel, A., Garbe, E. (2009). Citalopram-Induced Bleeding Due to Severe Thrombocytopenia. Psychosomatics 50: 297-298 [Abstract] [Full Text]  
• Rodeghiero, F., Stasi, R., Gernsheimer, T., Michel, M., Provan, D., Arnold, D. M., Bussel, J. B., Cines, D. B., Chong, B. H., Cooper, N., Godeau, B., Lechner, K., Mazzucconi, M. G., McMillan, R., Sanz, M. A., Imbach, P., Blanchette, V., Kuhne, T., Ruggeri, M., George, J. N. (2009). Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood 113: 2386-2393 [Abstract] [Full Text]  
• Bougie, D. W., Birenbaum, J., Rasmussen, M., Poncz, M., Aster, R. H. (2009). Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia. Blood 113: 1105-1111 [Abstract] [Full Text]  
• Kittisupamongkol, W. (2008). Incidence and Prognostic Significance of Thrombocytopenia in Patients Receiving Heparin Therapy. Arch Intern Med 168: 2170-2170 [Full Text]  
• Coller, B. S., Shattil, S. J. (2008). The GPIIb/IIIa (integrin {alpha}IIb{beta}3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood 112: 3011-3025 [Abstract] [Full Text]  
• Philip, A., Ramchandani, S., Dorrance, K., Dorrance, C. (2008). Sildenafil-Induced Thrombocytopenia. ANN INTERN MED 149: 437-439 [Full Text]  
• Pattis, P., Wiedermann, C. J (2008). Ezetimibe-Associated Immune Thrombocytopenia. The Annals of Pharmacotherapy 42: 430-433 [Abstract] [Full Text]  
• Peterson, J. A., Nelson, T. N., Kanack, A. J., Aster, R. H. (2008). Fine specificity of drug-dependent antibodies reactive with a restricted domain of platelet GPIIIA. Blood 111: 1234-1239 [Abstract] [Full Text]  
• Naina, H. V.K., Harris, S., Matzdorff, A. C., Cathomas, R., Goldhirsch, A., von Moos, R., Aster, R. H., Bougie, D. W. (2007). Drug-Induced Immune Thrombocytopenia. NEJM 357: 1869-1871 [Full Text]