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Previous Volume 357:580-587 August 9, 2007 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Drug-induced thrombocytopenia can be caused by dozens, perhaps hundreds, of medications. Because thrombocytopenia can have many other causes, the diagnosis of drug-induced thrombocytopenia can easily be overlooked. On occasion, outpatients with drug-induced thrombocytopenia are treated for autoimmune thrombocytopenia and can have two or three recurrences before the drug causing the disorder is identified.¹ In acutely ill, hospitalized patients, drug-induced thrombocytopenia can be overlooked because thrombocytopenia is attributed to sepsis, the effect of coronary-artery bypass surgery, or some other underlying condition. Although drug-induced thrombocytopenia is uncommon, it can have devastating, even fatal consequences that can usually be prevented simply by discontinuing . . . [Full Text of this Article]

Presentation

Incidence

Causative Agents

Pathogenesis

Thrombocytopenia Induced by Quinine and Other Drugs

Thrombocytopenia Induced by Platelet Inhibitors

Thrombocytopenia Induced by Abciximab

Thrombocytopenia Due to Drug-Induced Autoantibodies

Diagnosis

Treatment and Prognosis

Source Information

From the Department of Medicine, Medical College of Wisconsin (R.H.A.), and the Blood Research Institute, BloodCenter of Wisconsin (R.H.A., D.W.B.) — both in Milwaukee.

Address reprint requests to Dr. Aster at the Blood Research Institute, BloodCenter of Wisconsin, 8727 Watertown Plank Rd., Milwaukee, WI 53226-3548, or at richard.aster@bcw.edu.

Related Letters:

Drug-Induced Immune Thrombocytopenia
Naina H. V.K., Harris S., Matzdorff A. C., Cathomas R., Goldhirsch A., von Moos R., Aster R. H., Bougie D. W.
Extract | Full Text | PDF  
N Engl J Med 2007; 357:1869-1871, Nov 1, 2007. Correspondence

This article has been cited by other articles:

• Pattis, P., Wiedermann, C. J (2008). Ezetimibe-Associated Immune Thrombocytopenia. The Annals of Pharmacotherapy 42: 430-433 [Abstract] [Full Text]  
• Peterson, J. A., Nelson, T. N., Kanack, A. J., Aster, R. H. (2008). Fine specificity of drug-dependent antibodies reactive with a restricted domain of platelet GPIIIA. Blood 111: 1234-1239 [Abstract] [Full Text]  
• Naina, H. V.K., Harris, S., Matzdorff, A. C., Cathomas, R., Goldhirsch, A., von Moos, R., Aster, R. H., Bougie, D. W. (2007). Drug-Induced Immune Thrombocytopenia. NEJM 357: 1869-1871 [Full Text]