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Previous Volume 357:603-605 August 9, 2007 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Patients with severe hemophilia number only around 400,000 worldwide, but their lifespan has increased because of improved treatment, and with that the prevalence of the disease is increasing. Despite the relatively small number of patients with severe hemophilia, the disease has an important socioeconomic effect because of its distinctive feature: a level of clotting factor (factor VIII or factor IX) so low that without replacement therapy, frequent hemorrhages occur, most often in the ankle, knee, and elbow joints. These joint hemorrhages culminate in a severe arthropathy, with signs of inflammation (as in rheumatoid arthritis) as well as degenerative damage (as . . . [Full Text of this Article]

Source Information

From the Department of Hematology and Van Creveld Clinic and the Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.

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• Jansen, N W D, Roosendaal, G, Bijlsma, J W J, DeGroot, J, Theobald, M, Lafeber, F P J G (2008). Degenerated and healthy cartilage are equally vulnerable to blood-induced damage. Ann Rheum Dis 67: 1468-1473 [Abstract] [Full Text]