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Volume 357:715-717 August 16, 2007 Number 7
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Antiretroviral Drugs and the Risk of Myocardial Infarction

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 by The DAD Study Group
-PubMed Citation
To the Editor: We agree with the Perspective article by Hughes and Williams (April 26 issue)1 that a more detailed presentation of data from the well-conducted Data Collection on Adverse Effects of Anti-HIV Drugs (DAD) Study Group collaboration2 may help to disentangle several variables that potentially affect the risk of myocardial infarction among persons infected with human immunodeficiency virus type 1 (HIV-1). First, data on the nadir CD4+ lymphocyte count, but not the recent CD4+ count, were presented in relation to the risk of myocardial infarction. Inflammation may trigger an acute myocardial infarction by activating prothrombotic mechanisms, and the patient's . . . [Full Text of this Article]


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