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Previous Volume 357:720-722 August 16, 2007 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Nephrogenic systemic fibrosis is a newly described systemic disorder that occurs in patients with renal insufficiency.^1,2 The functional consequences of nephrogenic systemic fibrosis are often devastating and may be fatal. Since nephrogenic systemic fibrosis develops after exposure to gadolinium-containing magnetic resonance contrast agents in some patients,³ the Food and Drug Administration recommended avoiding such agents in patients with renal insufficiency. The mechanism by which nephrogenic systemic fibrosis develops after gadolinium exposure remains unknown.

Gadolinium is administered as a chelate, since free gadolinium is toxic. Metals such as iron are capable of inducing the dissociation of gadolinium from . . . [Full Text of this Article]

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