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The ancients recognized the effect of emotions on the pulse, but it wasn't until centuries later that the connection between emotions and heart disease was made. John Hunter, the eminent 18th-century surgeon who had angina pectoris, noted, "My life is in the hands of any rascal who chooses to annoy and tease me," and indeed, he died in the midst of an argument. In the early 1900s, Sir William Osler described his patients with coronary problems as "worriers" and his patients with angina as "men whose engines are always set at full speed ahead" — and this was 50 years
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