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A 44-year-old woman presented with increasing oral papillomatosis, predominantly on the lips and less pronounced on the tongue and buccal mucosa. The lips showed filiform papillomas in a symmetrical distribution (Panel A). The tongue was thickened and furrowed. A biopsy was performed, and histologic analysis revealed acanthosis and papillomatosis, hyperkeratosis, increased dermal pigmentation, and a dermal lymphohistiocytic infiltrate (Panel B and inset, arrows). No epidermal inclusion bodies were seen, and polymerase-chain-reaction analysis of the specimen did not detect any human papillomavirus DNA. The patient had received the diagnosis of advanced gastric adenocarcinoma 1 year earlier and had been treated with . . . [Full Text of this Article] |
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