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Almost a quarter of a century has passed since the human immunodeficiency virus (HIV) was identified, and from the outset one of the keys to recognition of the epidemic was the identification of Kaposi's sarcoma as a defining condition of AIDS. The effect of this disease worldwide has been staggering, particularly in sub-Saharan Africa, but a by-product has been considerable insight into the role of the immune system in the neoplastic process and into the role of oncogenic viruses — particularly Kaposi's sarcoma–associated herpesvirus and Epstein–Barr virus (EBV), but also human papillomavirus, hepatitis B virus (HBV), and hepatitis C virus
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