It cannot be emphasized too strongly that treatment of eachpatient is a highly individualized matter.
— FDA-approved labeling for warfarin (Coumadin) NDA 9-218/5-105
Pharmacogenomics is receiving a great deal of attention in scientificcircles and, increasingly, in the popular press because of thepromise of personalized medicine. Short of being able to curean illness or to prevent one, every clinician's dream is tooffer patients a precisely targeted drug at a precisely calibrateddose to address a specific ailment — and to do so withoutwreaking havoc on the rest of the body. We have ample reasonto . . . [Full Text of this Article]
Source Information
From the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
This article has been cited by other articles:
Wolverton, S. E.
(2009). Optimizing Clinical Use of Azathioprine With Newer Pharmacogenetic Data. Arch Dermatol
145: 707-710
[Full Text]
Garber, A. M., Tunis, S. R.
(2009). Does Comparative-Effectiveness Research Threaten Personalized Medicine?. NEJM
360: 1925-1927
[Full Text]
Roden, D. M., Stein, C. M.
(2009). Clopidogrel and the Concept of High-Risk Pharmacokinetics. Circulation
119: 2127-2130
[Full Text]
Li, C., Schwarz, U. I., Ritchie, M. D., Roden, D. M., Stein, C. M., Kurnik, D.
(2009). Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy. Blood
113: 3925-3930
[Abstract][Full Text]
The International Warfarin Pharmacogenetics Consor,
(2009). Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data. NEJM
360: 753-764
[Abstract][Full Text]
Schillinger, D., Neville, K. A., Wicklund, B. M., Kearns, G. L., Kulkarni, U. P., Karnad, D. R., Gogtay, N. J., Mannucci, P. M., Spreafico, M., Peyvandi, F., Stein, C. M., Roden, D. M., Schwarz, U. I.
(2008). Genetics of Warfarin Response. NEJM
358: 2741-2744
[Full Text]