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Volume 358:1073-1075 March 6, 2008 Number 10
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Chitinase-like Protein and Asthma

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by Chupp, G. L.
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To the Editor: In their descriptive study of a chitinase-like protein in patients with asthma, Chupp et al. (Nov. 15 issue)1 report elevated levels of YKL-40 (human cartilage glycoprotein 39 and chitinase 3–like 1) in the serum and lungs of patients with asthma. We measured YKL-40 concentrations in serum before and 24 hours after segmental allergen challenge,2 as well as in bronchoalveolar-lavage fluid 10 minutes and 24 hours after segmental allergen challenge, in 13 patients with allergic asthma, using the same enzyme-linked immunosorbent assay (Quidel). YKL-40 concentrations were significantly elevated in serum (P=0.01) and even more elevated in bronchoalveolar-lavage fluid . . . [Full Text of this Article]



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