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Clinical Implications of Basic Research
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Volume 358:1192-1193 March 13, 2008 Number 11
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Chemical Immunosuppression in Islet Transplantation — Friend or Foe?
Lucienne Chatenoud, M.D., Ph.D.

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Insulin-dependent (type 1) diabetes mellitus is an autoimmune disease caused by the selective destruction of pancreatic beta cells by CD4+ and CD8+ autoreactive T lymphocytes. The induction of effective and sustained beta-cell regeneration represents the holy grail of therapy for this disease. Will it ever be grasped?

A provocative study by Nir and colleagues1 suggests that the answer to this fundamental question is yes. The authors based their research on an experimental mouse model carrying a transgene that drives the expression of a beta-cell–targeted "toxic" insult — the diphtheria toxin (DTA). With this model, they showed that massive beta-cell regeneration . . . [Full Text of this Article]


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From the Université Paris Descartes and INSERM Unité 580 — both in Paris.



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