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Volume 358:1194-1195 March 13, 2008 Number 11
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TP53 Mutations in Head and Neck Cancer

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by Poeta, M. L.
To the Editor: Poeta et al. (Dec. 20 issue)1 report that a disruptive alteration of the gene for the tumor-suppressor protein p53 (TP53), as compared with the absence of a TP53 mutation, had an independent, significant association with decreased survival in patients with squamous-cell carcinoma of the head and neck. TP53 mutations were screened with the use of the GeneChip p53 assay (Affymetrix). However, frameshift mutations (from insertions or deletions in the p53 gene) cannot be detected with the GeneChip method.2,3 This important limitation biases the study by Poeta and colleagues because such frameshift mutations represent up to . . . [Full Text of this Article]



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