The use of blood transfusions in medicine is so well establishedthat the procedure is an afterthought to many physicians. Scientificadvances have rendered blood and blood products extremely safethrough the introduction of donor-deferral strategies, infectious-diseasetesting, pathogen-inactivation methods, and recombinant DNAtechnologies for particular therapeutic proteins. These advanceshave dramatically reduced the likelihood of transfusion-transmitteddisease so that the risk of transfusion-associated human immunodeficiencyvirus 1 or hepatitis C infection, for example, is now on theorder of 1 in 2 million donated units.1 Concern persists aboutthe transmission of other infectious agents, for which testingis not . . . [Full Text of this Article]
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From the Veterans Affairs San Diego Healthcare System, University of California at San Diego, San Diego.
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