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Volume 358:1301 March 20, 2008 Number 12
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Rosuvastatin in Older Patients with Systolic Heart Failure

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by Kjekshus, J.
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To the Editor: The Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA), as reported by Kjekshus et al. (Nov. 29 issue),1 failed to show a reduction in major vascular events with the use of rosuvastatin in older patients with systolic heart failure. One explanatory variable may be a reduction in coenzyme Q10, which is known to be caused by statins, as the authors mention in their introduction. Coenzyme Q10 is important in mitochondrial electron transport and energy generation, and depletion of coenzyme Q10 in myocardial tissue has been correlated with an increased clinical severity of heart failure.2 More recently, a . . . [Full Text of this Article]



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