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Editorial
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Volume 358:1392-1394 March 27, 2008 Number 13
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Effect of Mechanical Ventilation on the Diaphragm
Gary C. Sieck, Ph.D., and Carlos B. Mantilla, M.D., Ph.D.

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by Levine, S.
-PubMed Citation
It is widely assumed that respiratory-muscle weakness, either intrinsic or due to fatigue, leads to respiratory failure.1 For the past 30 years, attention has been focused on whether the diaphragm muscle is especially susceptible to fatigue in patients with chronic pulmonary disease and critical illness, increasing the potential for respiratory failure.2,3 In the 1980s and early 1990s, this concern led to the practice of resting the diaphragm with the use of mechanical ventilation to reverse fatigue. However, in studies examining transdiaphragmatic pressure in patients being weaned from mechanical ventilation, failure to wean was not consistently associated with a decrease in . . . [Full Text of this Article]


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From the Departments of Physiology and Biomedical Engineering and Anesthesiology, Mayo Clinic, Rochester, MN.



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