FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 358:1483-1494 April 3, 2008 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text PowerPoint Slide Set CME Exam Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

Atopic dermatitis, or eczema, is a common skin disease that is often associated with other atopic disorders, such as allergic rhinitis and asthma.¹ The clinical manifestations of atopic dermatitis (Figure 1) vary with age; three stages can often be identified. In infancy, the first eczematous lesions usually emerge on the cheeks and the scalp. Scratching, which frequently starts a few weeks later, causes crusted erosions. During childhood, lesions involve flexures, the nape, and the dorsal aspects of the limbs. In adolescence and adulthood, lichenified plaques affect the flexures, head, and neck. In each stage, itching that continues throughout . . . [Full Text of this Article]

Epidemiology of Atopic Dermatitis

Genetics of Atopic Dermatitis

Barrier Function of the Skin

Physical Barrier

The Innate Immune System

Immunopathologic Mechanisms of Atopic Dermatitis

Initial Mechanisms of Skin Inflammation

The Initiation Site of Sensitization

Dendritic Cells

A Biphasic T-Cell–Mediated Disease

Staphylococcus aureus

Mechanism of Pruritus

Autoimmunity in Atopic Dermatitis

A Unifying Hypothesis

Clinical Implications

Conclusions

Source Information

From the Department of Dermatology and Allergy, University of Bonn, Bonn, Germany.

Address reprint requests to Dr. Bieber at the Department of Dermatology and Allergy, University Medical Center, Sigmund-Freud-Str. 25, 53105 Bonn, Germany, or at thomas.bieber@ukb.uni-bonn.de.

This article has been cited by other articles:

• Zhang, Z., Hener, P., Frossard, N., Kato, S., Metzger, D., Li, M., Chambon, P. (2009). Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma. Proc. Natl. Acad. Sci. USA 106: 1536-1541 [Abstract] [Full Text]  
• Boehme, S. A., Franz-Bacon, K., Chen, E. P., Sasik, R., Sprague, L. J., Ly, T. W., Hardiman, G., Bacon, K. B. (2009). A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. Int Immunol 21: 81-93 [Abstract] [Full Text]  
• (2008). Review of Atopic Dermatitis. Journal Watch Dermatology 2008: 1-1 [Full Text]