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Previous Volume 358:1504-1507 April 3, 2008 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In this issue of the Journal, Kastelein et al.¹ report the results of a 2-year study comparing daily therapy with 80 mg of simvastatin plus either placebo or 10 mg of ezetimibe on the average change in carotid intima–media thickness in patients with familial hypercholesterolemia. The study, called the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) trial, showed no significant between-group differences in any of several end points with respect to intima–media thickness (a commonly used risk surrogate for vascular disease) or clinical results, despite a between-group difference in levels of low-density lipoprotein (LDL) cholesterol of 51 mg . . . [Full Text of this Article]

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From the University of Washington School of Medicine, Seattle (B.G.B.); and the Uniformed Services University of the Health Sciences, Bethesda, MD, and the Cardiology Service, Walter Reed Army Medical Center, Washington, DC (A.J.T.).

This article (10.1056/NEJMe0801608) was published at www.nejm.org on March 30, 2008.

Related Letters:

Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia
Steinberg D., Eichhorn E. J., Connor W. E., Diamond G. A., Kaul S., Blake J. A., Davis H. R. Jr., Murgolo N. J., Graziano M. P., Kaye T., Akdim F., de Groot E., Kastelein J. J.P., Brown B. G.
Extract | Full Text | PDF  
N Engl J Med 2008; 359:529-533, Jul 31, 2008. Correspondence

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