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FOCUS ON RESEARCH Previous Volume 358:1543-1545 April 10, 2008 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In this issue of the Journal, Watson-Jones et al. (pages 1560–1571) report anxiously awaited findings about a strategy for preventing infection with the human immunodeficiency virus (HIV) by pharmacologically suppressing herpes simplex virus type 2. Despite a sound rationale for the intervention, the results represent yet another disappointment in efforts to reduce the spread of HIV with the use of a biomedical agent.

Indeed, apart from important advances in preventing mother-to-child transmission, primarily through the use of antiretroviral drugs, and in preventing the acquisition of HIV in men by means of circumcision, only one late-stage randomized biomedical trial — involving . . . [Full Text of this Article]

Source Information

Dr. Lagakos is a professor of biostatistics at the Harvard School of Public Health, Boston, and a statistical consultant to the Journal. Ms. Gable is a senior program officer at the IOM, Washington, DC. Dr. Lagakos was the chair, and Ms. Gable the study director, of the IOM Committee on Methodological Challenges in Biomedical HIV Prevention Trials; the other committee members were as follows: Dr. Harvey J. Alter, National Institutes of Health; Dr. Ronald Bayer, Columbia University; Dr. Solomon R. Benatar, University of Cape Town; Dr. Ronald S. Brookmeyer, Johns Hopkins University; Dr. Carlos Del Rio, Emory University; Dr. David W. Feigal, Elan Pharmaceuticals; Dr. Els Goetghebeur, Ghent University; Dr. Laura A. Guay, Johns Hopkins University; Dr. Sally L. Hodder, University of Medicine and Dentistry of New Jersey; Dr. Shabbar Jaffar, London School of Hygiene and Tropical Medicine; Dr. Edward K. Kurumira, Makerere University; Dr. George W. Rutherford, University of California, San Francisco; Dr. Olive Shisana, South African Human Sciences Research Council; and Dr. Gina Wingood, Emory University.

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