The New England Journal of Medicine
e-mail icon  FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |    Advanced Search
Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe
 
Review Article
Medical Progress
PreviousPrevious
Volume 358:1590-1602 April 10, 2008 Number 15
NextNext

The Challenge of HIV-1 Subtype Diversity
Barbara S. Taylor, M.D., Magdalena E. Sobieszczyk, M.D., M.P.H., Francine E. McCutchan, Ph.D., and Scott M. Hammer, M.D.

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

 Sign up for free e-toc
 

This Article
-Full Text
- PDF
-PDA Full Text
-PowerPoint Slide Set
-Supplementary Material
-Purchase this article

Tools and Services
-Add to Personal Archive
-Add to Citation Manager
-Notify a Friend
-E-mail When Cited
-E-mail When Letters Appear

More Information
-PubMed Citation
Neary 27 years after the first reported cases of the acquired immunodeficiency syndrome (AIDS) and 25 years after the discovery of the etiologic agent, effective control of the AIDS pandemic remains elusive. At the root of this challenge is the molecular pathogenesis of human immunodeficiency virus (HIV) type 1 (HIV-1), a virus that has evolved a number of mechanisms to elude immune control. Among the most prominent of these are the heavy glycosylation of the external glycoprotein, which protects neutralization epitopes; the virus' direct targeting of the CD4 molecule expressed by the key T lymphocyte in immune orchestration; integration into . . . [Full Text of this Article]

Origin of HIV and Mechanisms of HIV Diversity

Classification and Molecular Epidemiology of HIV

Coreceptor Use by HIV-1 Subtypes, Transmission, and Disease Progression

Response to Therapy

Emergence of Resistance to Antiretroviral Therapy

Implications for Vaccine Development

Conclusions


Source Information



From the Department of Medicine and the Division of Infectious Diseases, Columbia University Medical Center, New York.

Address reprint requests to Dr. Taylor at Columbia University Medical Center, Department of Medicine, Division of Infectious Diseases, 630 W. 168th St., Pamp;S Box 82, New York, NY 10032, or at bs2026@columbia.edu.



HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  HELP  |  beta.nejm.org

Comments and questions? Please contact us.

The New England Journal of Medicine is owned, published, and copyrighted © 2008 Massachusetts Medical Society. All rights reserved.