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Previous Volume 358:1590-1602 April 10, 2008 Number 15 Next

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Nearly 27 years after the first reported cases of the acquired immunodeficiency syndrome (AIDS) and 25 years after the discovery of the etiologic agent, effective control of the AIDS pandemic remains elusive. At the root of this challenge is the molecular pathogenesis of human immunodeficiency virus (HIV) type 1 (HIV-1), a virus that has evolved a number of mechanisms to elude immune control. Among the most prominent of these are the heavy glycosylation of the external glycoprotein, which protects neutralization epitopes; the virus' direct targeting of the CD4 molecule expressed by the key T lymphocyte in immune orchestration; integration into . . . [Full Text of this Article]

Origin of HIV and Mechanisms of HIV Diversity

Classification and Molecular Epidemiology of HIV

Coreceptor Use by HIV-1 Subtypes, Transmission, and Disease Progression

Response to Therapy

Emergence of Resistance to Antiretroviral Therapy

Implications for Vaccine Development

Conclusions

Source Information

From the Department of Medicine and the Division of Infectious Diseases, Columbia University Medical Center, New York (B.S.T., M.E.S., S.M.H.) and the U.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD (F.E.M.).

Address reprint requests to Dr. Taylor at Columbia University Medical Center, Department of Medicine, Division of Infectious Diseases, 630 W. 168th St., Pamp;S Box 82, New York, NY 10032, or at bs2026@columbia.edu.

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