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Previous Volume 358:1644-1645 April 10, 2008 Number 15 Next

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By Barbara R. Migeon. 271 pp., illustrated. New York, Oxford University Press, 2007. $59.95. ISBN 978-0-19-518812-7.

In Females Are Mosaics, Barbara Migeon makes a very strong case that women are superior to men in coping with disease and the environment. This is because they have two types of cells in all their organs, each with one of the two X chromosomes genetically active and the other essentially silent. This allows adaptability, since each of the two X chromosomes carries different mutations and polymorphisms that can alter women's susceptibility or resistance to detrimental genes, infectious agents, or other environmental dangers.

Much of the book is devoted to the reason for this state of mosaicism, which allows males . . . [Full Text of this Article]

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