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Case Records of the Massachusetts General Hospital
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Volume 358:1713-1723 April 17, 2008 Number 16
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Case 12-2008 — A Newborn Infant with Intermittent Apnea and Seizures
Raymond W. Redline, M.D., Pallavi Sagar, M.D., Mary Etta King, M.D., Kalpathy S. Krishnamoorthy, M.D., Eric F. Grabowski, M.D., and Drucilla J. Roberts, M.D.

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Presentation of Case

A 1-day-old female infant was admitted to the neonatal intensive care unit of this hospital because of intermittent apnea and cyanosis. The day before admission, the patient was born at another hospital at 41 weeks 4 days' gestation to a 33-year-old primigravid mother. After 44 hours of labor, during which the amniotic membranes were artificially ruptured (17 hours before delivery) and the mother's temperature rose to 38.0°C, with a white-cell count of 26,700 per cubic millimeter, a cesarean section was performed because of failure of labor to progress. The infant weighed 4176 g (90th percentile) at birth, and the Apgar . . . [Full Text of this Article]

Differential Diagnosis

Chorioamnionitis

Apneic Spells

Neonatal Seizures

Perinatal Ischemic Stroke

            Fetal Thrombophilia

            Neonatal Infection

            Severe Placental–Fetal Vascular Lesions

Clinical Diagnosis

Dr. Raymond W. Redline's Diagnosis

Pathological Discussion

Discussion of Management

Anatomical Diagnosis


Source Information

From the Department of Pathology, University Hospitals Case Medical Center, Cleveland (R.W.R.); the Departments of Radiology (P.S.), Pediatric Cardiology (M.E.K.), Pediatric Neurology (K.S.K.), Pediatric Hematology/Oncology (E.F.G.), and Pathology (D.J.R.), Massachusetts General Hospital, Boston; the Department of Pathology , Case Western Reserve University School of Medicine, Cleveland (R.W.R.); and the Departments of Radiology (P.S.), Pediatrics (M.E.K., K.S.K., E.F.G.), and Pathology (D.J.R.), Harvard Medical School, Boston.


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