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Correspondence
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Volume 358:1753-1755 April 17, 2008 Number 16
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Lung Transplantation and Survival in Children with Cystic Fibrosis

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 by Allen, J.
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 by Liou, T. G.
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To the Editor: The analysis by Liou et al. (Nov. 22 issue)1 is a step toward a better understanding of the risk–benefit ratio of lung transplantation in cystic fibrosis. The study, however, has several limitations.

First, the authors have neither validated their model in an independent data set nor provided an indication of its discriminative ability. Unless the concordance statistic2 for the model was consistent with good discrimination of patients who survived from those who died, the study conclusions might not be applicable to a significant proportion of patients. Second, the model does not include any donor factors or surrogates . . . [Full Text of this Article]




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