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Correspondence
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Volume 358:1760-1761 April 17, 2008 Number 16
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Eosinophiluria and Acute Interstitial Nephritis

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To the Editor: Over the past two decades, testing for eosinophiluria has gained widespread acceptance as a means of screening for acute interstitial nephritis. The frequent use of this test may be explained, in part, by the subtle clinical presentation of this condition (fever, rash, arthralgia, and renal failure), which mimics other entities, such as pyelonephritis and renal manifestation of various systemic diseases. Renal biopsy, although used infrequently to diagnose acute interstitial nephritis, continues to be the gold standard.

The data on urinary eosinophil testing are inconsistent. A report in the Journal in 1986 by Nolan et al.1 states that . . . [Full Text of this Article]



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