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The successful manipulation of a cancer-directed immune response has long been a goal of cancer immunologists. Occasionally, spectacular successes have reinforced the enthusiasm of some investigators for this goal, but the more common failed attempts to manipulate the immune response have led many to conclude that other treatments will be more productive. These polarized views have been tempered by recent advances in the understanding of the elements and regulation of the immune response, and by the definition of how cancers evade immune recognition and disarm, divert, or destroy immune effector mechanisms. Many authorities believe that new treatment strategies that address
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