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Previous Volume 358:1855-1856 April 24, 2008 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Malaria, a tremendously successful pathogen that is responsible for more than 300 million cases and 1 million deaths annually,¹ has had a large impact on the shape of the human genome. Malaria-selected mutations in human genes promote survival in areas where malaria is endemic. The parasite's substantive effect on the human genome is due to its high prevalence in areas where it is endemic and its long history of coevolution with humans. Moreover, its marked genetic diversity, generated by its sexual stage, provides the organism with many opportunities to maximally adapt to host defenses and continue transmission. In this issue . . . [Full Text of this Article]

Source Information

This article (10.1056/NEJMe0801414) was published at www.nejm.org on April 16, 2008.

From Brigham and Women's Hospital, Boston, and the Broad Institute, Cambridge, MA.

This article has been cited by other articles:

• Teo, Y. Y., Fry, A. E., Bhattacharya, K., Small, K. S., Kwiatkowski, D. P., Clark, T. G. (2009). Genome-wide comparisons of variation in linkage disequilibrium. Genome Res 19: 1849-1860 [Abstract] [Full Text]  
• (2008). Escape from Malaria -- The Pyruvate Kinase Connection. JWatch Infect. Diseases 2008: 1-1 [Full Text]