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Previous Volume 358:1960-1962 May 1, 2008 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The days when the microscope was the principal tool for classifying the various forms of acute myeloid leukemia (AML) and predicting the outcome of affected patients seem long past. The discovery, during the past 15 years, of acquired mutations and alterations in gene expression in the leukemic cells in all varieties of AML has not only changed the role of the microscope in diagnosing leukemia but also influenced the management of these diseases and how we think about their causes. Genomic alterations in AML affect the function of signaling molecules, transcription factors, and growth-factor receptors and also determine the phenotype . . . [Full Text of this Article]

Source Information

From the Department of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands.

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