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Volume 358:2075 May 8, 2008 Number 19
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Chimerism and Tolerance in a Recipient of a Deceased-Donor Liver Transplant

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by Alexander, S. I.
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To the Editor: Since the role of hepatotropic viruses in severe aplastic anemia is well established,1 we suggest that the presumptive viral infection in the patient described by Alexander et al. (Jan. 24 issue)2 affected liver and hematopoietic cells simultaneously. The lymphopenia was noted at the onset of the liver failure, which, in turn, could have resulted in partial myeloablation, providing bone marrow niches for stem-cell engraftment. Fortuitously for the recipient, the death of the liver donor involved a hypoxemic brain injury, which may have mobilized bone marrow stem cells, as seen in patients with acute myocardial infarction or stroke.3,4 . . . [Full Text of this Article]



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